Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 6/20 | 0.40 |
| ▸ | MMP9 | P14780 | 9/20 | 0.38 |
| ▸ | MMP13 | P45452 | 5/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313925 | 0.94 | MEN1 (0.41) | MEN1KMT2ANAMPTMMP9MMP13 | |
| SCHEMBL7316303 | 0.93 | MEN1 (0.42) | MEN1KMT2ANAMPTMMP9MMP13 | |
| SCHEMBL7311152 | 0.90 | MMP9 (0.42) | MEN1KMT2ANAMPTMMP9MMP13 | |
| SCHEMBL7320922 | 0.90 | NAMPT (0.44) | MEN1KMT2ANAMPTMMP9MMP13 | |
| SCHEMBL7321334 | 0.85 | NAMPT (0.42) | NAMPTMMP9MMP13MMP1ADAM17 | |
| SCHEMBL7317943 | 0.84 | MMP9 (0.41) | MEN1KMT2ANAMPTMMP9MMP13 | |
| SCHEMBL7317842 | 0.83 | MMP9 (0.45) | MEN1KMT2ANAMPTMMP9MMP13 | |
| SCHEMBL7324058 | 0.83 | NAMPT (0.49) | NAMPTMMP9MMP13MMP1ADAM17 | |
| SCHEMBL7319145 | 0.81 | NAMPT (0.47) | NAMPTMMP9MMP13MMP1ADAM17 | |
| SCHEMBL7317439 | 0.81 | MMP13 (0.49) | NAMPTMMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |