Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14374414 | 0.79 | ALDH1A1 (0.48) | TP53NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL265221 | 0.74 | KDM4E (0.36) | L3MBTL1 | |
| SCHEMBL12963698 | 0.73 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL22229890 | 0.73 | BMP1 (0.41) | TP53NPC1RAB9ASMN1; SMN2BMP1 | |
| SCHEMBL12626 | 0.73 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2BMP1ALDH1A1 | |
| SCHEMBL7317347 | 0.73 | SMPD1 (0.32) | L3MBTL1 | |
| SCHEMBL14034348 | 0.69 | BMP1 (0.45) | NPC1RAB9ASMN1; SMN2BMP1CYP1A2 | |
| SCHEMBL14006362 | 0.69 | TSHR (0.41) | NPC1RAB9ASMN1; SMN2BMP1ALDH1A1 | |
| SCHEMBL7263917 | 0.67 | HSD17B10 (0.42) | TP53RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2888294 | 0.67 | MAPT (0.43) | SMN1; SMN2MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4705786-A | Novel oxadiazolyl-1,4-dihydropyridines useful as antihypertensive agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-11-10 | — | — | US | disclosed |