Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27285239 | 0.98 | TDP1 (0.65) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL4301966 | 0.78 | HTR2A (0.67) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL9051157 | 0.78 | SIGMAR1 (0.48) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL7326678 | 0.78 | HTR2A (0.67) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL25256282 | 0.78 | SLC6A2 (0.52) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL2252400 | 0.78 | HTR2A (0.44) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL25852267 | 0.78 | AOC3 (0.49) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL31664264 | 0.78 | SLC6A2 (0.52) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4374402 | 0.77 | HTR2A (0.64) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL10915686 | 0.77 | TDP1 (0.41) | HTR2AHRH1TDP1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761796-A | Aryl derivatives for the treatment of TRPM3 mediated disorders | 勒芬天主教大学 | 2023-09-15 | — | — | CN | disclosed |
| WO-2022112345-A1 | ARYL DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2022-06-02 | — | — | WO | disclosed |
| US-20170217905-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| US-9662330-B2 | Aminopyrimidine derivatives for use as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2017-05-30 | — | — | US | disclosed |
| US-20160184308-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-9321760-B2 | Aminopyrimidine derivatives for use as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2016-04-26 | — | — | US | disclosed |
| US-20150126484-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2015-05-07 | — | — | US | disclosed |
| CN-1027262-C | Benzazepine and benzothiazepine derivatives | E R SQUID & SONS INC (US) | 1995-01-04 | — | — | CN | disclosed |
| US-4902684-A | Benzazepine and benzothiazepine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1990-02-20 | — | — | US | disclosed |
| CN-1039585-A | BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | SQUIBB & SONS INC (US) | 1990-02-14 | — | — | CN | disclosed |
| WO-1989012633-A1 | BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | E.R. SQUIBB & SONS, INC. (US) | 1989-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217905-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | CDK6, TK1, MAP3K19 | HTR2A 2982/4885HRH1 1245/4885TDP1 445/4885 |
| US-20150126484-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | CDK6, TK1, MAP3K19 | HTR2A 2982/4885HRH1 1245/4885TDP1 445/4885 |
| US-20160184308-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | CDK6, TK1, MAP3K19 | HTR2A 2982/4885HRH1 1245/4885TDP1 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.