Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | ARG2 | P78540 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | GGT1 | P19440 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18036525 | 1.00 | MEN1 (0.41) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6882712 | 0.86 | MEN1 (0.46) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2485254 | 0.80 | MEN1 (0.39) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7253604 | 0.79 | ALDH1A1 (0.41) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL16568741 | 0.77 | MEN1 (0.40) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22612005 | 0.77 | ALDH1A1 (0.40) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL681314 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2HIF1AARG1ARG2BLM | |
| SCHEMBL27553149 | 0.75 | MEN1 (0.39) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4361740 | 0.75 | MEN1 (0.39) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7034666 | 0.73 | MEN1 (0.38) | MEN1CYP1A2KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229420-A | Renin inhibitor | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0349921-A2 | Etheral n-terminal aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | disclosed |