Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697450 | 0.87 | CYP1A2 (0.48) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL27758693 | 0.85 | CYP1A2 (0.46) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL11297959 | 0.84 | HDAC3 (0.45) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL7300322 | 0.81 | CNR2 (0.44) | SIGMAR1 | |
| SCHEMBL1177110 | 0.80 | CTSC (0.42) | CYP1A2MEN1KMT2A | |
| SCHEMBL7294571 | 0.80 | CSNK1E (0.50) | — | |
| SCHEMBL985725 | 0.79 | CTSL (0.39) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL5049235 | 0.79 | EPHX1 (0.46) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL8759048 | 0.79 | CYP1A2 (0.42) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL5050487 | 0.79 | EPHX1 (0.46) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180305404-A1 | NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE | ALPHABETA AB (SE) | 2018-10-25 | — | — | US | disclosed |
| US-10023610-B2 | Ligands for prevention of neurotoxicity of the alzheimer's disease related amyloid-beta peptide | ALPHABETA AB (SE) | 2018-07-17 | — | — | US | disclosed |
| US-20160340387-A1 | NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE | ALPHABETA AB (SE) | 2016-11-24 | — | — | US | disclosed |
| EP-3094641-A1 | NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE | Alphabeta AB (SE) | 2016-11-23 | — | — | EP | disclosed |
| WO-2015107170-A1 | NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE | ALPHABETA AB (SE) | 2015-07-23 | — | — | WO | disclosed |
| EP-0327877-A2 | Peptide-renininhibitors | MERCK PATENT GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |
| EP-0292800-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023610-B2 | Ligands for prevention of neurotoxicity of the alzheimer's disease related amyloid-beta peptide | APP, BACE1, PSEN1 | TRPA1 2934/4885TAAR1 911/4885SIGMAR1 1818/4885 |
| US-20160340387-A1 | NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE | APP, BACE1, PSEN1 | TRPA1 3028/4885TAAR1 910/4885SIGMAR1 1631/4885 |
| US-20180305404-A1 | NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE | APP, BACE1, PSEN1 | TRPA1 3028/4885TAAR1 910/4885SIGMAR1 1631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.