Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 14/20 | 0.44 |
| ▸ | MMP1 | P03956 | 9/20 | 0.44 |
| ▸ | MMP3 | P08254 | 9/20 | 0.44 |
| ▸ | MMP7 | P09237 | 4/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300322 | 0.95 | CNR2 (0.44) | CSNK1ECNR2MMP2MMP1 | |
| SCHEMBL11297959 | 0.87 | HDAC3 (0.45) | CSNK1E | |
| SCHEMBL10349571 | 0.84 | SIGMAR1 (0.44) | — | |
| SCHEMBL7279390 | 0.82 | SIGMAR1 (0.42) | — | |
| SCHEMBL9542370 | 0.81 | HTR2A (0.46) | MMP2 | |
| SCHEMBL7320079 | 0.80 | TRPA1 (0.46) | — | |
| SCHEMBL5935806 | 0.79 | CYP1A2 (0.43) | CNR2MMP2MMP3 | |
| SCHEMBL1697450 | 0.79 | CYP1A2 (0.48) | — | |
| SCHEMBL30032419 | 0.79 | CSNK1E (0.47) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL7318322 | 0.79 | TAAR1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401722-A | Peptide analogues | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-03-28 | — | — | US | disclosed |
| EP-0501280-A2 | Renin-inhibiting peptide analogues | MERCK PATENT GmbH (DE) | 1992-09-02 | — | — | EP | disclosed |
| EP-0446485-A2 | Peptide analogues with renininhibiting activity | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0339483-A2 | Renin inhbiting amino-acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-02 | — | — | EP | disclosed |
| EP-0327877-A2 | Peptide-renininhibitors | MERCK PATENT GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |
| EP-0292800-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |