Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320102 | 1.00 | HPGD (0.66) | HPGDSMN1; SMN2GFERCYP2A6CYP3A4 | |
| SCHEMBL3649780 | 0.80 | HPGD (1.00) | HPGDSMN1; SMN2GFERCYP2A6CYP3A4 | |
| SCHEMBL3649775 | 0.80 | HPGD (1.00) | HPGDSMN1; SMN2GFERCYP2A6CYP3A4 | |
| SCHEMBL7328684 | 0.79 | ALDH1A1 (0.64) | HPGDSMN1; SMN2CYP3A4NR4A1NR4A2 | |
| SCHEMBL4340043 | 0.78 | MAPT (0.72) | HPGDSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL4340042 | 0.78 | MAPT (0.72) | HPGDSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL7436062 | 0.75 | SMN1; SMN2 (0.66) | HPGDSMN1; SMN2GFERCYP2A6CYP3A4 | |
| SCHEMBL30938668 | 0.72 | NR4A1 (0.64) | CYP2A6CYP3A4NR4A1NR4A2NR4A3 | |
| SCHEMBL29273198 | 0.72 | NR4A1 (0.64) | CYP2A6CYP3A4NR4A1NR4A2NR4A3 | |
| SCHEMBL13035362 | 0.72 | CYP2A6 (1.00) | HPGDSMN1; SMN2GFERCYP2A6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |