Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10496397 | 0.90 | P2RX7 (0.43) | ROCK2ROCK1P2RX7NR3C1ALDH1A1 | |
| SCHEMBL7327226 | 0.88 | ROCK2 (0.48) | ROCK2ROCK1P2RX7LMNAF2 | |
| SCHEMBL7319421 | 0.88 | ROCK2 (0.48) | ROCK2ROCK1P2RX7LMNAF2 | |
| SCHEMBL10496402 | 0.88 | ROCK2 (0.48) | ROCK2ROCK1P2RX7LMNAF2 | |
| SCHEMBL7316438 | 0.88 | ROCK2 (0.48) | ROCK2ROCK1P2RX7LMNAF2 | |
| SCHEMBL7322591 | 0.86 | ROCK2 (0.45) | ROCK2ROCK1P2RX7NR3C1LMNA | |
| SCHEMBL7326031 | 0.86 | ROCK2 (0.46) | ROCK2ROCK1P2RX7NR3C1LMNA | |
| SCHEMBL10496387 | 0.85 | ROCK2 (0.42) | ROCK2ROCK1P2RX7NR3C1LMNA | |
| SCHEMBL7322056 | 0.85 | P2RX7 (0.44) | ROCK2ROCK1P2RX7NR3C1ALDH1A1 | |
| SCHEMBL10496437 | 0.84 | ROCK2 (0.43) | ROCK2ROCK1P2RX7LMNAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| US-4798897-A | (AMINOALKYL)AMINOSULFONYL-SUBSTITUTED CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-01-17 | — | — | US | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |