Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237141 | 0.86 | ADRB2 (0.65) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL13077710 | 0.84 | ADRB2 (0.53) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL13077713 | 0.84 | ADRB2 (0.53) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL13077711 | 0.83 | ADRB2 (0.52) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL4268855 | 0.83 | ADRB2 (0.64) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL31119470 | 0.82 | ADRB2 (0.60) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL31119471 | 0.82 | ADRB2 (0.60) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL13040059 | 0.82 | ADRB2 (0.50) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL13040061 | 0.82 | ADRB2 (0.50) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL14571125 | 0.81 | ADRB2 (0.49) | ADRB2ADRB1ADRB3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4171370-A | Phenoxy-amino-propanols | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-10-16 | — | — | US | disclosed |