Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4268855 | 0.87 | ADRB2 (0.64) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL7320264 | 0.86 | ADRB2 (0.60) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL31119471 | 0.84 | ADRB2 (0.60) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL31119470 | 0.84 | ADRB2 (0.60) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL5381741 | 0.82 | ADRB2 (0.71) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL7310868 | 0.82 | ADRB2 (0.71) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL29688096 | 0.82 | ADRB2 (0.70) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| SCHEMBL27167630 | 0.80 | ADRB2 (0.74) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| Bisoprolol SCHEMBL6510329 | 0.79 | ADRB1 (1.00) | ADRB2ADRB1ADRB3MAPK1MEN1 | |
| Bisoprolol SCHEMBL233810 | 0.79 | ADRB1 (1.00) | ADRB2ADRB1ADRB3MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300292-A1 | Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders | NITROMED, INC (US) | 2008-12-04 | — | — | US | disclosed |
| WO-2007069266-A2 | A NOVEL PROCESS FOR THE SYNTHESIS OF BISODPROLOL AND ITS INTERMEDIATE | UNICHEM LABORATORIES LIMITED (IN) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300292-A1 | Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders | NOS3, NOS1, NOS2 | ADRB2 33/4885ADRB1 26/4885ADRB3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.