Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | RXRB | P28702 | 4/20 | 0.66 |
| ▸ | RXRA | P19793 | 3/20 | 0.66 |
| ▸ | RXRG | P48443 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 3/20 | 0.59 |
| ▸ | PPARD | Q03181 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729878 | 0.83 | TSHR (0.93) | TSHRALOX15HSD17B10RXRBRXRA | |
| SCHEMBL6527201 | 0.80 | TSHR (1.00) | TSHRALOX15HSD17B10RXRBRXRA | |
| SCHEMBL9720056 | 0.79 | PPARG (0.64) | TSHRALOX15HSD17B10RXRBRXRA | |
| SCHEMBL21052066 | 0.77 | MAOB (0.67) | — | |
| SCHEMBL13254657 | 0.77 | BRD4 (0.60) | TSHRALOX15HSD17B10RXRBRXRA | |
| SCHEMBL21052051 | 0.77 | MAOB (0.60) | — | |
| SCHEMBL21052060 | 0.77 | MAOB (0.60) | — | |
| SCHEMBL30778174 | 0.76 | TSHR (0.60) | TSHRALOX15HSD17B10RXRBRXRA | |
| SCHEMBL23222346 | 0.76 | SMN1; SMN2 (0.56) | TSHRALOX15HSD17B10KDM4EPOLB | |
| SCHEMBL3150833 | 0.76 | SMN1; SMN2 (0.56) | TSHRALOX15HSD17B10RXRBRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733908-A | USEFUL IN THE TREATMENT OF PARKINSON'S DISEASE AND SCHIZOPHRENIA | ADIR ET COMPAGNIE (FR) | 1998-03-31 | — | — | US | disclosed |