Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439500 | 0.87 | ALOX15 (0.54) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9720056 | 0.84 | PPARG (0.64) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL15625501 | 0.81 | KDM4E (0.60) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL29825051 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7214609 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL23222346 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10602491 | 0.81 | TSHR (0.59) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9796002 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1799468 | 0.79 | PDK2 (0.47) | ALDH1A1LMNA | |
| SCHEMBL9720055 | 0.79 | ALOX15 (0.59) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389183-B1 | SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2010-03-03 | — | — | EP | disclosed |
| US-7109203-B2 | Sulfonamide derivatives | NOVARTIS AG (CH) | 2006-09-19 | — | — | US | disclosed |
| US-20040127533-A1 | Sulfonamide derivatives | NOVARTIS AG (CH) | 2004-07-01 | — | — | US | disclosed |
| EP-1389183-A1 | SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002092556-A1 | SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127533-A1 | Sulfonamide derivatives | BDKRB1, BDKRB2, BRS3 | SMN1; SMN2 2071/4885NPC1 1847/4885RAB9A 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.