Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19756653 | 0.80 | TUBB1 (0.39) | NFE2L2CYP19A1ALDH1A1LMNAGAA | |
| SCHEMBL24016981 | 0.76 | ACHE (0.40) | CYP19A1NQO2ALDH1A1MAPTLMNA | |
| SCHEMBL20855333 | 0.76 | ACHE (0.45) | CYP19A1NQO2ALDH1A1MAPTGAA | |
| SCHEMBL6149994 | 0.74 | ALDH1A1 (0.43) | NFE2L2CYP19A1ALDH1A1MAPTTUBB1 | |
| SCHEMBL16952213 | 0.73 | CA1 (0.42) | NFE2L2NQO2ALDH1A1MAPTLMNA | |
| SCHEMBL1226775 | 0.73 | ALDH1A1 (0.46) | CYP19A1NQO2ALDH1A1MAPTLMNA | |
| SCHEMBL29767819 | 0.73 | ALDH1A1 (0.46) | CYP19A1NQO2ALDH1A1MAPTLMNA | |
| SCHEMBL11454393 | 0.73 | DYRK1A (0.39) | NFE2L2ALDH1A1MAPTLMNAGAA | |
| SCHEMBL14699980 | 0.73 | MAPT (0.60) | ALDH1A1MAPTLMNATUBB1KDM4E | |
| SCHEMBL12648260 | 0.72 | TUBB1 (0.42) | NFE2L2CYP19A1NQO2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4359464-A | 3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof | SMITHKLINE BECKMAN CORPORATION (US) | 1982-11-16 | — | — | US | disclosed |
| US-4352754-A | HYPOTENSIVE, ANTI-PARKINSON | SMITHKLINE CORPORATION (US) | 1982-10-05 | — | — | US | disclosed |
| US-4255422-A | DIURETICS, TREATMENT OF CARDIOVASCULAR DISORDERS | SMITHKLINE CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4192872-A | ANTI -PARKINSONISM ACTIVITY | SMITHKLINE CORPORATION (US) | 1980-03-11 | — | — | US | disclosed |
| US-4187314-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1980-02-05 | — | — | US | disclosed |
| US-4160765-A | Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds | SMITHKLINE CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |
| US-4111957-A | DOPAMINERGIC | SMITHKLINE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |
| US-4104379-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1978-08-01 | — | — | US | disclosed |