Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.33 |
| ▸ | PDE2A | O00408 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376003 | 1.00 | PDE3B (0.36) | PDE3BPDE3AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10376980 | 0.99 | PDE3B (0.36) | PDE3BPDE3AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10376684 | 0.96 | PDE3B (0.38) | PDE3BPDE3AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10375692 | 0.88 | PLA2G1B (0.38) | L3MBTL1SMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL10376920 | 0.87 | PDE3B (0.45) | PDE3BPDE3AALDH1A1MAPTP2RY12 | |
| SCHEMBL10374689 | 0.87 | PDE3B (0.45) | PDE3BPDE3AALDH1A1MAPTP2RY12 | |
| SCHEMBL10374824 | 0.87 | ALDH1A1 (0.38) | PDE3BPDE3AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10376931 | 0.86 | PDE3B (0.45) | PDE3BPDE3AALDH1A1MAPTP2RY12 | |
| SCHEMBL10374675 | 0.84 | PDE3B (0.39) | PDE3BPDE3AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7310674 | 0.84 | SMN1; SMN2 (0.35) | PDE3BPDE3AL3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116948-B1 | (2-OXO-1,2,3,5-TETRAHYDROIMIDAZO-(2,1-B)QUINAZOLINYL)-OXYALKYL-AMIDES | SYNTEX (U.S.A.) INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4670434-A | ANTICOAGULANT, INOTROPIC AGENT | SYNTEX (U.S.A.) INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4663320-A | ANTITUMOR AGENTS, ANTICOAGULANTS | SYNTEX (U.S.A.) INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4551459-A | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides | SYNTEX (U.S.A.) INC. (US) | 1985-11-05 | — | — | US | disclosed |
| US-4490371-A | ANTICOAGULANTS, PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0116948-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides | SYNTEX (U.S.A.) INC. (US) | 1984-08-29 | — | — | EP | disclosed |