Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338607 | 0.98 | POLB (0.73) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL7325677 | 0.98 | POLB (0.73) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL7338599 | 0.98 | POLB (0.73) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL6375231 | 0.88 | POLB (0.60) | POLBALDH1A1HSD17B10KMT2ACYP3A4 | |
| SCHEMBL6375227 | 0.88 | POLB (0.60) | POLBALDH1A1HSD17B10KMT2ACYP3A4 | |
| SCHEMBL7298853 | 0.87 | POLB (0.70) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL7266885 | 0.87 | POLB (0.74) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL7266801 | 0.87 | POLB (0.70) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL5193787 | 0.87 | POLB (0.74) | POLBALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL7275964 | 0.87 | POLB (0.74) | POLBALDH1A1HSD17B10KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |