Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321590 | 0.81 | MEN1 (0.45) | MEN1KMT2AGAAPKMPOLB | |
| SCHEMBL17154335 | 0.72 | POLB (0.63) | MEN1KMT2APOLBTSHRLOXL2 | |
| SCHEMBL10563866 | 0.71 | POLB (0.49) | MEN1KMT2AGAAPKMPOLB | |
| Paranitrobenzyl Alcohol SCHEMBL114620 | 0.70 | TSHR (0.69) | POLBTSHRLOXL2ALDH1A1CYP2C19 | |
| SCHEMBL8087428 | 0.70 | POLB (0.76) | MEN1KMT2APOLBTSHRLOXL2 | |
| SCHEMBL8094050 | 0.70 | POLB (0.76) | MEN1KMT2APOLBTSHRLOXL2 | |
| SCHEMBL44366 | 0.70 | POLB (0.76) | MEN1KMT2APOLBTSHRLOXL2 | |
| SCHEMBL9136851 | 0.69 | POLB (0.63) | MEN1KMT2APOLBTSHRLOXL2 | |
| SCHEMBL8185024 | 0.69 | TSHR (0.49) | MEN1KMT2AGAAPKMPOLB | |
| SCHEMBL3887887 | 0.66 | TSHR (0.89) | MEN1KMT2APOLBTSHRLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000001674-A1 | PROCESS FOR MAKING 1,5-DISUBSTITUTED IMIDAZOLES | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |
| EP-0253310-A2 | Angiotensin II receptor blocking imidazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |