Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313463 | 0.90 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7311435 | 0.88 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7317733 | 0.88 | ALDH1A1 (0.38) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7351300 | 0.88 | LCK (0.36) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7311535 | 0.80 | MAPT (0.37) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7310780 | 0.78 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7311511 | 0.77 | ALDH1A1 (0.35) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7319179 | 0.77 | LCK (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7311440 | 0.74 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7319536 | 0.71 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761416-A | ENZYME INHIBITORS, INOTROPIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0254327-A2 | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-01-27 | — | — | EP | disclosed |