Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 11/20 | 0.67 |
| ▸ | AVPR2 | P30518 | 8/20 | 0.67 |
| ▸ | OXTR | P30559 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332412 | 0.86 | AVPR1A (0.50) | AVPR1AAVPR2 | |
| SCHEMBL7415990 | 0.82 | AVPR2 (0.50) | AVPR1AAVPR2 | |
| SCHEMBL7338976 | 0.82 | AVPR1A (0.51) | AVPR1AAVPR2HPGD | |
| SCHEMBL3554976 | 0.80 | AVPR1A (1.00) | AVPR1AAVPR2 | |
| SCHEMBL7416297 | 0.79 | HSD11B1 (0.47) | — | |
| SCHEMBL4138509 | 0.75 | AVPR1A (0.69) | AVPR1AAVPR2 | |
| SCHEMBL7340725 | 0.75 | AVPR2 (0.48) | AVPR1AAVPR2OXTRHPGDPOLB | |
| SCHEMBL7410950 | 0.75 | AVPR2 (0.53) | AVPR1AAVPR2 | |
| SCHEMBL7331708 | 0.75 | AVPR2 (0.59) | AVPR1AAVPR2OXTR | |
| SCHEMBL7417248 | 0.75 | AVPR2 (0.60) | AVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805813-B1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID CO (US) | 2002-05-15 | — | — | EP | claimed |
| US-5780471-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-07-14 | — | — | US | claimed |
| WO-1996022292-A1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |
| EP-0805813-B1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID CO (US) | 2002-05-15 | — | — | EP | disclosed |
| US-5780471-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1996022292-A1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5521173-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |