Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293970 | 1.00 | MME (0.56) | MMEHTR2CSLC6A3MAPK1MMP8 | |
| SCHEMBL7294452 | 0.90 | MME (0.61) | MMEHTR2C | |
| SCHEMBL7295886 | 0.83 | HTR2C (0.40) | MMEHTR2CSLC6A3MAPK1MMP8 | |
| SCHEMBL7294105 | 0.83 | MME (0.82) | MMEMMP8 | |
| SCHEMBL7301621 | 0.73 | MME (1.00) | MMEMAPK1MMP8 | |
| SCHEMBL7294573 | 0.72 | MME (0.57) | MME | |
| SCHEMBL7294567 | 0.72 | MME (0.57) | MME | |
| Bicarbonate SCHEMBL7323197 | 0.71 | MME (0.48) | MME | |
| SCHEMBL7293268 | 0.71 | MME (0.48) | MME | |
| SCHEMBL7293478 | 0.70 | MME (0.47) | MMEHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | disclosed |