Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 1.00 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294105 | 0.90 | MME (0.82) | MMEMMP8HDAC9 | |
| SCHEMBL7300905 | 0.79 | MME (0.64) | MMEMMP8HDAC9 | |
| SCHEMBL7294394 | 0.77 | MME (0.63) | MMEMMP8HDAC9HPGD | |
| SCHEMBL7294452 | 0.76 | MME (0.61) | MMEACE | |
| SCHEMBL7303084 | 0.74 | MME (0.57) | MMEMMP8ACE | |
| SCHEMBL7293970 | 0.73 | MME (0.56) | MMEMMP8MAPK1 | |
| SCHEMBL7320924 | 0.73 | MME (0.56) | MMEMMP8MAPK1 | |
| SCHEMBL7294378 | 0.73 | MME (0.56) | MME | |
| SCHEMBL7292661 | 0.72 | MME (0.55) | MMEMMP8 | |
| SCHEMBL30492730 | 0.71 | MMP8 (0.61) | MMEMMP8HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | disclosed |