Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.82 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301621 | 0.90 | MME (1.00) | MMEMMP8HDAC9 | |
| SCHEMBL7294452 | 0.87 | MME (0.61) | MME | |
| SCHEMBL7293970 | 0.83 | MME (0.56) | MMEMMP8 | |
| SCHEMBL7320924 | 0.83 | MME (0.56) | MMEMMP8 | |
| SCHEMBL7292661 | 0.82 | MME (0.55) | MMEMMP8 | |
| SCHEMBL7303084 | 0.81 | MME (0.57) | MMEMMP8 | |
| SCHEMBL7294378 | 0.80 | MME (0.56) | MME | |
| SCHEMBL7294573 | 0.78 | MME (0.57) | MME | |
| SCHEMBL7294567 | 0.78 | MME (0.57) | MME | |
| SCHEMBL7291958 | 0.78 | ERCC1 (0.50) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516980-B1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMA INC (US) | 1996-04-17 | — | — | EP | claimed |
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | claimed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | claimed |
| JP-5208952-A | — | — | None | — | — | JP | disclosed |
| EP-0516980-B1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMA INC (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |
| JP-H05208952-A | NOVEL 2-MERCAPTOMETHYLENE-TETRAHYDRONAPHTHALENE OR INDANE-2-CARBOXAMIDE DERIVATIVE AS ENKEPHALINASE INHIBITOR | MERRELL DOW PHARMACEUT INC | 1993-08-20 | — | — | JP | disclosed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | disclosed |