Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1717108 | 0.91 | TSHR (0.38) | LRRK2TSHRMEN1ALDH1A1LMNA | |
| SCHEMBL31194597 | 0.83 | TSHR (0.42) | TSHRMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL31194470 | 0.80 | HPGD (0.46) | TSHRMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL1717600 | 0.80 | HPGD (0.49) | TSHRMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL4498872 | 0.79 | HPGD (0.51) | FLT3TSHRMEN1ALDH1A1LMNA | |
| SCHEMBL8553968 | 0.77 | ALOX15 (0.48) | LRRK2TSHRMEN1ALDH1A1LMNA | |
| SCHEMBL18988586 | 0.75 | ADORA2A (0.40) | LRRK2PI4KBFLT3MAP3K1MEN1 | |
| SCHEMBL18988152 | 0.75 | ADORA2A (0.40) | LRRK2PI4KBFLT3MAP3K1MEN1 | |
| SCHEMBL18988527 | 0.75 | ADORA2A (0.40) | LRRK2PI4KBFLT3MAP3K1MEN1 | |
| SCHEMBL31735524 | 0.74 | PDE4D (0.33) | MAP3K12PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |