Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31194597 | 0.89 | TSHR (0.42) | ALOX15GAATSHRHPGDKMT2A | |
| SCHEMBL1717600 | 0.86 | HPGD (0.49) | GAATSHRHPGDKMT2AALDH1A1 | |
| SCHEMBL31194470 | 0.86 | HPGD (0.46) | ALOX15GAATSHRHPGDKMT2A | |
| SCHEMBL4498872 | 0.84 | HPGD (0.51) | TSHRHPGDKMT2AALDH1A1LMNA | |
| SCHEMBL1717108 | 0.82 | TSHR (0.38) | GAATSHRHPGDKMT2AALDH1A1 | |
| SCHEMBL7317011 | 0.77 | MAPT (0.40) | GAASMN1; SMN2TSHRHPGDKMT2A | |
| SCHEMBL8554183 | 0.77 | TSHR (0.58) | TSHRHRH3POLB | |
| SCHEMBL7320980 | 0.77 | LRRK2 (0.37) | GAATSHRHPGDKMT2AALDH1A1 | |
| SCHEMBL7316681 | 0.73 | TSHR (0.38) | TSHRHPGDKMT2AALDH1A1LMNA | |
| SCHEMBL16513295 | 0.72 | SMN1; SMN2 (0.51) | ALOX15GAASMN1; SMN2HPGDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885890-A1 | SULFONYLUREIDOPYRAZOLE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |