Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11471701 | 0.88 | ALDH1A1 (0.46) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL9495357 | 0.84 | RAB9A (0.53) | SMN1; SMN2HSD17B10POLBALDH1A1TSHR | |
| SCHEMBL1504839 | 0.84 | ALDH1A1 (0.55) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL11189770 | 0.79 | ALDH1A1 (0.48) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL14782241 | 0.78 | NPC1 (0.51) | SMN1; SMN2HSD17B10POLBALDH1A1TSHR | |
| SCHEMBL8332586 | 0.78 | SMN1; SMN2 (0.48) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL6643050 | 0.78 | SMN1; SMN2 (0.63) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL11798694 | 0.78 | MEN1 (0.45) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL6335581 | 0.77 | SMN1; SMN2 (0.66) | TRPM8SMN1; SMN2HSD17B10POLBALDH1A1 | |
| SCHEMBL22660208 | 0.76 | POLB (0.53) | SMN1; SMN2HSD17B10POLBALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4680392-A | Substituted caprolactam derivatives as antihypertensives | MERCK & CO., INC. (US) | 1987-07-14 | — | — | US | disclosed |
| US-4629787-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1986-12-16 | — | — | US | disclosed |
| US-4594341-A | Hypotensive agent | MERCK & CO., INC. (US) | 1986-06-10 | — | — | US | disclosed |
| US-4587050-A | Substituted enantholactam derivatives as antihypertensives | MERCK & CO., INC. (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0068173-B1 | PERHYDRO-1,4-THIAZEPIN-5-ONE AND PERHYDRO-1,4-THIAZOCIN-5-ONE DERIVATIVES, PROCESS FOR PREPARING AND PHARMCEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-09-26 | — | — | EP | disclosed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0068173-A1 | Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |
| EP-0065301-A1 | Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-11-24 | — | — | EP | disclosed |