Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390717 | 0.87 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7387697 | 0.86 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7389939 | 0.85 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7389555 | 0.85 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7317457 | 0.84 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7389100 | 0.84 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7389162 | 0.84 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL8691674 | 0.82 | PDE4D (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8691675 | 0.82 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7334529 | 0.80 | PDE4B (0.47) | PDE4APDE4DPDE4BPDE4CEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5962492-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5780478-A | Tetra-substituted phenyl derivatives | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| US-5780477-A | Trisubstituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |
| US-5723460-A | Cyclo (alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-03-03 | — | — | US | disclosed |