Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390717 | 0.84 | PDE4A (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7321981 | 0.80 | PDE4A (0.52) | PDE4BPDE4DPDE4APDE4CEPHX2 | |
| SCHEMBL7387697 | 0.76 | PDE4A (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7389939 | 0.75 | PDE4A (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8688517 | 0.74 | PDE4A (0.50) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7389555 | 0.74 | PDE4A (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7911028 | 0.73 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CEPHX2 | |
| SCHEMBL7389162 | 0.73 | PDE4A (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7389100 | 0.73 | PDE4A (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7334522 | 0.72 | PDE4A (0.61) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | claimed |
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | disclosed |