Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038800 | 0.86 | LMNA (0.52) | LMNAPLAUNOS1IDO1KDM4E | |
| SCHEMBL17298238 | 0.86 | LMNA (0.46) | LMNANOS1IDO1KDM4EALDH1A1 | |
| SCHEMBL28468532 | 0.83 | LMNA (0.44) | LMNAPLAUIDO1KDM4EALDH1A1 | |
| SCHEMBL31211054 | 0.83 | LMNA (0.50) | LMNAIDO1KDM4EALDH1A1 | |
| SCHEMBL9797756 | 0.78 | NOS1 (0.43) | LMNANOS1IDO1KDM4EALDH1A1 | |
| SCHEMBL67272 | 0.78 | PLAU (0.43) | LMNAPLAUKDM4E | |
| SCHEMBL30029657 | 0.78 | LMNA (0.50) | LMNAPLAUIDO1KDM4EALDH1A1 | |
| SCHEMBL68280 | 0.78 | LMNA (0.50) | LMNAPLAUIDO1KDM4EALDH1A1 | |
| SCHEMBL17427737 | 0.77 | LMNA (0.39) | LMNAIDO1ALDH1A1 | |
| SCHEMBL31289724 | 0.77 | LMNA (0.39) | LMNAIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0348392-A1 | 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | Université Montpellier I (FR) | 1990-01-03 | — | — | EP | disclosed |
| WO-1988004298-A1 | 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1988-06-16 | — | — | WO | disclosed |