Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318633 | 0.89 | SCN3A (0.48) | MAPTGSK3BCSNK2A1SCN3ANPC1 | |
| SCHEMBL7321908 | 0.85 | MAPT (0.70) | MAPTGSK3BCSNK2A1NPC1ALDH1A1 | |
| SCHEMBL7313264 | 0.83 | GSK3B (0.46) | GSK3BCSNK2A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7315745 | 0.82 | MAPT (0.47) | MAPTGSK3BCSNK2A1SCN3ANPC1 | |
| SCHEMBL7315480 | 0.81 | GSK3B (0.58) | MAPTGSK3BCSNK2A1NPC1ALDH1A1 | |
| SCHEMBL7319160 | 0.81 | DRD3 (0.49) | GSK3BCSNK2A1 | |
| SCHEMBL7325736 | 0.79 | NPC1 (0.42) | GSK3BCSNK2A1NPC1RAB9A | |
| SCHEMBL7319478 | 0.79 | NPC1 (0.48) | GSK3BCSNK2A1SCN3ANPC1RAB9A | |
| SCHEMBL7312903 | 0.79 | NPC1 (0.54) | MAPTGSK3BCSNK2A1NPC1ALDH1A1 | |
| Bromide SCHEMBL7319918 | 0.77 | MAPT (0.47) | MAPTGSK3BCSNK2A1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886812-A | REGULATING DOPAMINE CONCENTRATION; PARKINSON DISEASE, HYPOTENSIVE AGENT, SCHIZOPHRENIA | DR. KARL THOMAE GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4843086-A | HYPOTENSIVE AGENTS, SCHIZOPHRENIA, PARKINSON'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1989-06-27 | — | — | US | disclosed |
| US-4731374-A | PARKINSON*S DISEASE | DR. KARL THOMAE GMBH (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0186087-A1 | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs | Dr. Karl Thomae GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |