SCHEMBL7322645

SCHEMBL7322645

O=C(O)CCCNC(=O)C(Cc1ccc(-c2ccccc2)cc1)NC(c1ccccc1)P(=O)(O)O

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMEL1 Q495T6 1/20 0.52
ACP3 P15309 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7320404 0.96 MMEL1 (0.50) MMEL1ACP3
SCHEMBL7310433 0.93 MMEL1 (0.60) MMEL1ACP3
SCHEMBL7309970 0.89 MMEL1 (0.55) MMEL1ACP3
SCHEMBL7313035 0.89 MMEL1 (0.55) MMEL1ACP3
SCHEMBL7341084 0.86 MMEL1 (0.55) MMEL1
SCHEMBL7322147 0.86 MMEL1 (0.55) MMEL1
SCHEMBL7313712 0.85 MMEL1 (0.53) MMEL1
SCHEMBL7317538 0.84 MMEL1 (0.52) MMEL1ACP3
SCHEMBL7316768 0.83 MMEL1 (0.55) MMEL1
SCHEMBL7309923 0.83 GCGR (0.54) MMEL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0511940-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1992-11-04 EP claimed
EP-0592367-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1994-04-13 EP disclosed
US-5294632-A Diuretics and vasorelaxants CIBA-GEIGY CORPORATION (US) 1994-03-15 US disclosed
EP-0511940-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1992-11-04 EP disclosed
US-5155100-A Treating cardiovascular disorders in mammals CIBA-GEIGY CORPORATION (US) 1992-10-13 US disclosed