Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11361421 | 0.92 | PPARA (0.62) | PPARAPOLBAPEX1RECQLHPGD | |
| SCHEMBL7324522 | 0.91 | PPARA (0.76) | PPARAPOLBAPEX1RECQLHPGD | |
| SCHEMBL11356908 | 0.91 | PPARA (0.61) | PPARAPOLBAPEX1RECQLHPGD | |
| SCHEMBL11361843 | 0.88 | PPARA (0.59) | PPARAPOLBAPEX1RECQLHPGD | |
| SCHEMBL2838316 | 0.86 | PPARA (0.56) | PPARAPOLBAPEX1RECQLHPGD | |
| SCHEMBL11398411 | 0.85 | PPARA (0.55) | PPARAPOLBAPEX1RECQLHPGD | |
| SCHEMBL11368015 | 0.85 | PPARA (0.65) | PPARAALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL7331187 | 0.84 | PPARA (1.00) | PPARAHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL11370453 | 0.84 | PPARA (0.74) | PPARAALDH1A1 | |
| SCHEMBL11368265 | 0.84 | PPARA (0.82) | PPARAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067685-B1 | ALPHA-PHENYL-2-(AZA)BENZOTHIAZOLYLTHIOGLYCOLIC ACIDS AND DERIVATIVES THEREOF | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-11-05 | — | — | EP | claimed |
| US-4567267-A | α-Phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-01-28 | — | — | US | claimed |
| US-4367233-A | ALPHA-PHENYL-2-/AZA/BENZOTHIAZOYLTHIOGLYCOLIC ACIDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-01-04 | — | — | US | claimed |
| EP-0067685-B1 | ALPHA-PHENYL-2-(AZA)BENZOTHIAZOLYLTHIOGLYCOLIC ACIDS AND DERIVATIVES THEREOF | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-11-05 | — | — | EP | disclosed |
| US-4567267-A | α-Phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-01-28 | — | — | US | disclosed |
| US-4367233-A | ALPHA-PHENYL-2-/AZA/BENZOTHIAZOYLTHIOGLYCOLIC ACIDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-01-04 | — | — | US | disclosed |
| EP-0067685-A1 | Alpha-phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-12-22 | — | — | EP | disclosed |
| US-4294839-A | Benzothiazole derivatives and pharmaceutical formulations containing them | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-10-13 | — | — | US | disclosed |
| EP-0030632-A2 | Benzothiazole derivatives, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1981-06-24 | — | — | EP | disclosed |