Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.59 |
| ▸ | ACE2 | Q9BYF1 | 11/20 | 0.59 |
| ▸ | ACE | P12821 | 11/20 | 0.59 |
| ▸ | CPA1 | P15085 | 9/20 | 0.54 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348036 | 1.00 | MME (0.59) | MMEACE2ACECPA1ACP3 | |
| SCHEMBL7412452 | 0.88 | HDAC1 (0.52) | MMEACE2ACECPA1ACP3 | |
| SCHEMBL7318671 | 0.88 | HDAC1 (0.52) | MMEACE2ACECPA1ACP3 | |
| SCHEMBL7407171 | 0.83 | MME (0.50) | MMEACE2ACECPA1ACP3 | |
| SCHEMBL7407179 | 0.83 | MME (0.50) | MMEACE2ACECPA1ACP3 | |
| SCHEMBL7309944 | 0.82 | MMEL1 (0.61) | MMEACE | |
| SCHEMBL7415374 | 0.82 | MMEL1 (0.50) | MMEACE2ACEACP3 | |
| SCHEMBL7415381 | 0.82 | MMEL1 (0.50) | MMEACE2ACEACP3 | |
| SCHEMBL739018 | 0.81 | ACE (0.51) | MMEACE2ACECPA1 | |
| SCHEMBL73700 | 0.81 | ACE (0.51) | MMEACE2ACECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996026729-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES AS ECE INHIBITORS | CIBA-GEIGY AG (CH) | 1996-09-06 | — | — | WO | disclosed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0660840-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES. | CIBA GEIGY AG (CH) | 1995-07-05 | — | — | EP | disclosed |
| EP-0592367-A2 | Phosphono/biaryl substituted dipeptide derivatives | CIBA-GEIGY AG (CH) | 1994-04-13 | — | — | EP | disclosed |
| WO-1994005677-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1994-03-17 | — | — | WO | disclosed |
| US-5294632-A | Diuretics and vasorelaxants | CIBA-GEIGY CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |
| US-5250522-A | Neutral endopeptidase inhibitors; cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0511940-A2 | Phosphono/biaryl substituted dipeptide derivatives | CIBA-GEIGY AG (CH) | 1992-11-04 | — | — | EP | disclosed |
| US-5155100-A | Treating cardiovascular disorders in mammals | CIBA-GEIGY CORPORATION (US) | 1992-10-13 | — | — | US | disclosed |