Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81831 | 0.97 | TDP1 (0.70) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| Ammonia Solution, Strong SCHEMBL27512246 | 0.95 | TDP1 (0.67) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| Hydrochloric Acid SCHEMBL28970403 | 0.95 | TDP1 (0.67) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| SCHEMBL1007355 | 0.95 | TDP1 (0.67) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| Ethylene SCHEMBL28160202 | 0.92 | TDP1 (0.64) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| Fluoride Ion SCHEMBL5446842 | 0.92 | TDP1 (0.64) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| Propane SCHEMBL28091962 | 0.90 | TDP1 (0.61) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| SCHEMBL28792071 | 0.90 | TDP1 (0.67) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| SCHEMBL80789 | 0.90 | TDP1 (0.67) | TDP1SIGMAR1MAOAMAOBADRA1A | |
| SCHEMBL2404356 | 0.87 | TDP1 (0.64) | TDP1SIGMAR1MAOAMAOBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262431-A | Treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| EP-0275482-B1 | PROLINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-5112847-A | PROLINAL DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROLYL ENDOPEPTIDASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |
| US-4983624-A | Anemia | ONO PHARMACEUTICAL CO., LTD (JP) | 1991-01-08 | — | — | US | disclosed |
| EP-0275482-A2 | Proline derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-07-27 | — | — | EP | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |