SCHEMBL2404356

SCHEMBL2404356

BrCCCCCCCCCCCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.64
SIGMAR1 Q99720 9/20 0.58
MAOA P21397 1/20 0.56
MAOB P27338 2/20 0.54
MAPT P10636 1/20 0.54
RXFP1 Q9HBX9 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.50
HDAC1 Q13547 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7624612 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL854090 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL1773132 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL7612611 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL7563162 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL11806608 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL2162933 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL79441 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL17027772 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT
SCHEMBL3310359 1.00 TDP1 (0.64) TDP1SIGMAR1MAOAMAOBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140296485-A1 ANIONIC DISPLACER MOLECULES FOR HYDROPHOBIC DISPLACEMENT CHROMATOGRAPHY PNC BANK, NATIONAL ASSOCIATION 2014-10-02 US disclosed
US-20110295029-A1 NANOPARTICLE DISPERSIONS WITH LOW AGGREGATION LEVELS LUCENT TECHNOLOGIES, INC. (US) 2011-12-01 US disclosed
US-8012564-B2 Nanoparticle dispersions with low aggregation levels ALCATEL LUCENT (FR) 2011-09-06 US disclosed
US-20080017848-A1 NANOPARTICLE DISPERSIONS WITH LOW AGGREGATION LEVELS LUCENT TECHNOLOGIES (US) 2008-01-24 US disclosed
CN-1105558-C 2,2-dichloroalkane carboxylic acids, process for preparing the same, medicament containing the same and use for treating insulin resistance ROCHE DIAGNOSTICS GMBH (DE) 2003-04-16 CN disclosed
EP-0790824-B1 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE ROCHE DIAGNOSTICS GMBH (DE) 2002-02-06 EP disclosed
US-5968982-A TREATMENT OF DIABETES ROCHE DIAGNOSTICS GMBH (DE) 1999-10-19 US disclosed
CN-1171050-A 2, 2-Dichloroalkanecarboxylic acids, method for the production thereof, medicaments containing the same and use thereof for the treatment of insulin resistance BOEHRINGER MANNHEIM GMBH (DE) 1998-01-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110295029-A1 NANOPARTICLE DISPERSIONS WITH LOW AGGREGATION LEVELS CCNO, FLOT1, TSPO TDP1 1202/4885SIGMAR1 1102/4885MAOA 2748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.