Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346871 | 0.83 | KCNH2 (0.46) | KCNH2RAB9ADRD4 | |
| SCHEMBL7357788 | 0.80 | HTR7 (0.55) | KCNH2RAB9AHTR7 | |
| SCHEMBL27416355 | 0.74 | KCNH2 (0.45) | KCNH2RAB9ADRD4 | |
| SCHEMBL7383392 | 0.74 | KCNH2 (0.51) | KCNH2HTR7DRD4 | |
| SCHEMBL7346867 | 0.73 | SLC6A2 (0.46) | KCNH2RAB9ASLC6A2SLC6A4 | |
| SCHEMBL7324117 | 0.73 | CHRM1 (0.48) | KCNH2RAB9ADRD4 | |
| SCHEMBL7348366 | 0.72 | KCNH2 (0.46) | KCNH2RAB9ADRD4 | |
| Hydrochloric Acid SCHEMBL7533243 | 0.72 | HTR7 (0.41) | KCNH2RAB9AHTR7 | |
| Hydrochloric Acid SCHEMBL7537449 | 0.71 | HTR7 (0.40) | KCNH2RAB9AHTR7 | |
| SCHEMBL7346874 | 0.70 | KCNH2 (0.46) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708174-A | Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-01-13 | — | — | US | claimed |
| WO-1994008994-A1 | HETEROCYCLIC -ESTERS OR -AMIDES USED AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | claimed |
| US-5708174-A | Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-01-13 | — | — | US | disclosed |