Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037791 | 0.90 | ATM (0.47) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL2108878 | 0.86 | ATM (0.49) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL8695089 | 0.86 | ATM (0.45) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL7898208 | 0.86 | ATM (0.45) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL7898194 | 0.82 | TDP1 (0.49) | ATML3MBTL1MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL2558679 | 0.79 | MTNR1A (0.42) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL5503297 | 0.77 | EDNRB (0.44) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL2046224 | 0.76 | ALOX15 (0.44) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL5822084 | 0.75 | ATM (0.45) | ATML3MBTL1MTNR1AMTNR1BGAA | |
| SCHEMBL16753741 | 0.74 | PLG (0.41) | ATML3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |