Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.54 |
| ▸ | METAP1 | P53582 | 5/20 | 0.54 |
| ▸ | BHMT | Q93088 | 5/20 | 0.41 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322982 | 1.00 | METAP2 (0.54) | METAP2METAP1BHMTBHMT2NOD1 | |
| SCHEMBL10681733 | 1.00 | METAP2 (0.54) | METAP2METAP1BHMTBHMT2NOD1 | |
| SCHEMBL24335665 | 0.85 | METAP2 (0.47) | METAP2METAP1BHMTBHMT2NOS2 | |
| SCHEMBL17901898 | 0.85 | METAP2 (0.43) | METAP2METAP1BHMTBHMT2NOS2 | |
| SCHEMBL1839255 | 0.84 | NOD1 (0.40) | METAP2METAP1BHMTBHMT2NOD1 | |
| SCHEMBL1839254 | 0.84 | NOD1 (0.40) | METAP2METAP1BHMTBHMT2NOD1 | |
| Hydrochloric Acid SCHEMBL6776434 | 0.83 | METAP2 (0.46) | METAP2METAP1BHMTBHMT2NOS2 | |
| Hydrochloric Acid SCHEMBL6776435 | 0.83 | METAP2 (0.46) | METAP2METAP1BHMTBHMT2NOS2 | |
| SCHEMBL113611 | 0.82 | METAP2 (0.53) | METAP2METAP1NOD1ALOX15CYP2D6 | |
| SCHEMBL5443843 | 0.82 | METAP2 (0.53) | METAP2METAP1NOD1ALOX15CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262436-A | Administering; enzyme inhibitor | SCHERING CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5100786-A | Gene capable of enhancing S-adenosyl-L-methionine accumulation and process for producing S-adenosyl-L-methionine using the same | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1992-03-31 | — | — | US | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |
| EP-0073143-A2 | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides | Ryan, James Walter (US) | 1983-03-02 | — | — | EP | disclosed |