Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15720845 | 0.84 | ALDH1A1 (0.59) | SMN1; SMN2KDM4EALDH1A1GAATP53 | |
| SCHEMBL9080270 | 0.81 | GAA (0.51) | SMN1; SMN2KDM4EALDH1A1HPGDGAA | |
| SCHEMBL16533945 | 0.81 | SYK (0.53) | SMN1; SMN2L3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL15517531 | 0.80 | EPHX2 (0.53) | SMN1; SMN2KDM4EALDH1A1GAATP53 | |
| SCHEMBL15720776 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2KDM4EALDH1A1GAATP53 | |
| SCHEMBL15517496 | 0.80 | EPHX2 (0.53) | SMN1; SMN2KDM4EALDH1A1GAATP53 | |
| SCHEMBL16533977 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1GAALMNA | |
| SCHEMBL1417060 | 0.79 | L3MBTL1 (0.66) | SMN1; SMN2L3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL501720 | 0.78 | ATM (0.76) | ATMSMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16533854 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958929-A | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS | SANOFI (FR) | 1999-09-28 | — | — | US | disclosed |
| US-5736548-A | CYCLIC GUANOSINE 3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; TREATING HEART FAILURE, HYPERTENSION | SANOFI (FR) | 1998-04-07 | — | — | US | disclosed |
| WO-1996028448-A1 | 6-ARYL PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-09-19 | — | — | WO | disclosed |