Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556364 | 0.86 | MMP8 (0.52) | MMP8PIN1ALDH1A1EPHX2PPARG | |
| SCHEMBL7353961 | 0.86 | MMP8 (0.52) | MMP8PIN1ALDH1A1EPHX2PPARG | |
| SCHEMBL2208261 | 0.84 | CYP1A2 (0.53) | ALDH1A1L3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL7335349 | 0.84 | SMN1; SMN2 (0.51) | MMP8PIN1ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL23489851 | 0.80 | ALPI (0.48) | NPC1LMNAPOLBMMP1MMP9 | |
| SCHEMBL7332824 | 0.78 | PPARG (0.52) | MMP8PIN1ALDH1A1EPHX2PPARG | |
| SCHEMBL7346855 | 0.78 | EPHX1 (0.51) | ALDH1A1L3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL10521821 | 0.78 | MMP8 (0.61) | MMP8PIN1ALDH1A1EPHX2PPARG | |
| SCHEMBL892960 | 0.78 | MMP8 (0.61) | MMP8PIN1ALDH1A1EPHX2PPARG | |
| SCHEMBL165382 | 0.78 | MMP8 (0.76) | MMP8PIN1ALDH1A1EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914129-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4889869-A | ANTIALDOSTERONISM AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |