Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5921 | 0.89 | LMNA (0.57) | L3MBTL1LMNAALDH1A1 | |
| SCHEMBL7323045 | 0.84 | MMP8 (0.54) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 | |
| SCHEMBL5923 | 0.82 | MEN1 (0.41) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL14125663 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTMMP8TDP1MEN1 | |
| SCHEMBL4224537 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 | |
| SCHEMBL935980 | 0.79 | TDP1 (0.59) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 | |
| SCHEMBL18065697 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 | |
| SCHEMBL3991999 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 | |
| SCHEMBL614649 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 | |
| SCHEMBL8224624 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTPIN1MMP8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914129-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4889869-A | ANTIALDOSTERONISM AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |