Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9138493 | 0.95 | SIGMAR1 (0.53) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL9137258 | 0.91 | L3MBTL1 (0.50) | SIGMAR1CYP3A4HTR1ADRD2TSHR | |
| Hydrochloric Acid SCHEMBL9870487 | 0.80 | SIGMAR1 (0.57) | SIGMAR1PARP1CYP1A2CYP3A4HTR1A | |
| Hydrochloric Acid SCHEMBL9240174 | 0.79 | SIGMAR1 (0.51) | SIGMAR1PARP1HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL9154481 | 0.79 | GRIN2B (0.57) | SIGMAR1PARP1HTR1ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL8593986 | 0.76 | GRIN2B (0.55) | SIGMAR1CYP3A4HTR1ADRD2TSHR | |
| SCHEMBL7297566 | 0.76 | SIGMAR1 (0.63) | SIGMAR1PARP1HTR1ADRD2DRD4 | |
| SCHEMBL7270081 | 0.75 | SIGMAR1 (0.51) | SIGMAR1PARP1CYP1A2HTR1AMAPT | |
| Hydrochloric Acid SCHEMBL7327180 | 0.75 | SIGMAR1 (0.57) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL10332834 | 0.74 | SIGMAR1 (0.53) | SIGMAR1PARP1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592453-B1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AG (DE) | 1998-12-16 | — | — | EP | disclosed |
| US-5424312-A | Treating central nervous system disorders, high blood pressure | BASF AKTIENGESELLSCHAFT (DE) | 1995-06-13 | — | — | US | disclosed |
| EP-0592453-A1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1994-04-20 | — | — | EP | disclosed |
| WO-1992022541-A1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1992-12-23 | — | — | WO | disclosed |