Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 14/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401627 | 0.78 | HTR4 (0.56) | HTR4ADRA2CHTR1DHTR2BHTR3A | |
| SCHEMBL8321572 | 0.72 | HTR4 (0.56) | HTR4ADRA1BCHRM4CHRM5CHRM3 | |
| SCHEMBL4151143 | 0.71 | HTR4 (0.46) | HTR4ADRA2CHTR1DHTR2BHTR3A | |
| Hydrochloric Acid SCHEMBL7498481 | 0.71 | HTR4 (0.55) | HTR4ADRA1BCHRM4CHRM5CHRM3 | |
| SCHEMBL7391971 | 0.70 | HTR4 (0.45) | HTR4ADRA2CHTR1DHTR2BHTR3A | |
| SCHEMBL7323178 | 0.70 | HTR4 (0.72) | HTR4ADRA2CHTR1DHTR2BHTR3A | |
| Hydrochloric Acid SCHEMBL7417007 | 0.69 | HTR4 (0.46) | HTR4ADRA1BCHRM4CHRM5CHRM3 | |
| SCHEMBL7411902 | 0.69 | HTR4 (0.46) | HTR4ADRA1BCHRM4CHRM5CHRM3 | |
| SCHEMBL7405651 | 0.69 | HTR4 (0.55) | HTR4ADRA1BCHRM4CHRM5CHRM3 | |
| SCHEMBL7401623 | 0.69 | HTR4 (0.52) | HTR4ADRA2CHTR1DHTR2BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994008994-A1 | HETEROCYCLIC -ESTERS OR -AMIDES USED AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | claimed |
| US-5708174-A | Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-01-13 | — | — | US | disclosed |
| WO-1994008994-A1 | HETEROCYCLIC -ESTERS OR -AMIDES USED AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | disclosed |