Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7417007 | 0.90 | HTR4 (0.46) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7402155 | 0.85 | HTR4 (0.38) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7392357 | 0.82 | HTR4 (0.38) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7405651 | 0.81 | HTR4 (0.55) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8321572 | 0.80 | HTR4 (0.56) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL7498481 | 0.79 | HTR4 (0.55) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7421133 | 0.78 | CHRM1 (0.42) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7401627 | 0.76 | HTR4 (0.56) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7391971 | 0.76 | HTR4 (0.45) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL7248497 | 0.76 | HTR3A (0.53) | HTR4CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127379-A | TREATING IRRITABLE BOWEL SYNDROME, URINARY INCONTINENCE, ATRIAL ARRHYTHMIA OR STROKE | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-10-03 | — | — | US | disclosed |
| EP-0625149-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993016072-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-19 | — | — | WO | disclosed |