Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | UBE2M | P61081 | 2/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7319312 | 0.99 | HRH3 (0.56) | HRH3HTR1AHTR7DRD2LTA4H | |
| Hydrochloric Acid SCHEMBL7326837 | 0.89 | HTR1A (0.51) | HRH3HTR1AHTR7ALDH1A1HTT | |
| SCHEMBL9532091 | 0.89 | HRH3 (0.50) | HRH3HTR1AHTR7DRD2LTA4H | |
| SCHEMBL7325097 | 0.86 | HTR1A (0.51) | HRH3HTR1AHTR7DRD2ALDH1A1 | |
| SCHEMBL7321415 | 0.86 | HRH3 (0.54) | HRH3DRD2LTA4HKMT2A | |
| Hydrochloric Acid SCHEMBL27342157 | 0.85 | HTR1A (0.50) | HRH3HTR1AHTR7DRD2ALDH1A1 | |
| SCHEMBL7326091 | 0.85 | HRH3 (0.67) | HRH3LMNAHTTKMT2A | |
| Hydrochloric Acid SCHEMBL9528342 | 0.84 | HRH3 (0.65) | HRH3LMNAHTTKMT2A | |
| SCHEMBL23315180 | 0.84 | HRH3 (0.68) | HRH3HTR1AHTR7DRD2LTA4H | |
| SCHEMBL7322566 | 0.83 | TMEM97 (0.61) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542846-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-05-26 | — | — | EP | claimed |
| WO-1992002502-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-02-20 | — | — | WO | claimed |