Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 15/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CTRC | Q99895 | 2/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316705 | 0.94 | CMA1 (0.50) | CMA1CTRCELANEITGB3ITGA2B | |
| SCHEMBL7314093 | 0.91 | CMA1 (0.51) | CMA1CTRCELANEMMP1MMP3 | |
| SCHEMBL7320775 | 0.91 | CMA1 (0.51) | CMA1CTRCELANEMMP1MMP3 | |
| SCHEMBL7309936 | 0.87 | ITGB3 (0.59) | CMA1ACEITGB3ITGA2B | |
| SCHEMBL7312175 | 0.82 | ITGB3 (0.58) | CMA1ITGB3ITGA2B | |
| SCHEMBL7322601 | 0.82 | ITGB3 (0.57) | CMA1ITGB3ITGA2B | |
| SCHEMBL10791046 | 0.81 | CMA1 (0.49) | CMA1ACECTRCELANE | |
| SCHEMBL7320588 | 0.81 | MALT1 (0.59) | ACEITGB3ITGA2B | |
| SCHEMBL7317534 | 0.80 | ITGB3 (0.55) | CMA1ITGB3ITGA2B | |
| SCHEMBL7322422 | 0.79 | ITGB3 (0.64) | CMA1ACEITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |