Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327409 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7327536 | 0.87 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL7321843 | 0.86 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7326043 | 0.79 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7323406 | 0.76 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7324380 | 0.74 | SERPINE1 (0.40) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7327414 | 0.73 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7318384 | 0.73 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7327379 | 0.72 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL7325121 | 0.72 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557408-A4 | IMIDAZOLIDINONE COMPOUNDS | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0557408-A1 | IMIDAZOLIDINONE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992007567-A1 | IMIDAZOLIDINONE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-05-14 | — | — | WO | disclosed |