Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.43 |
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323406 | 0.89 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7327409 | 0.78 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7327539 | 0.76 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DEPHX2 | |
| SCHEMBL7320525 | 0.76 | SERPINE1 (0.42) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7321848 | 0.75 | POLB (0.44) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7323403 | 0.73 | PDE4A (0.43) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL9272449 | 0.71 | ALDH1A1 (0.57) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL16056331 | 0.71 | KMT2A (0.53) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7364116 | 0.70 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL7423009 | 0.70 | PDE4D (0.76) | PDE4BPDE4APDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557408-A4 | IMIDAZOLIDINONE COMPOUNDS | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0557408-A1 | IMIDAZOLIDINONE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992007567-A1 | IMIDAZOLIDINONE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-05-14 | — | — | WO | disclosed |