Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.77 |
| ▸ | HPGD | P15428 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.71 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.71 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.71 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.71 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.71 |
| ▸ | BRD4 | O60885 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CNR1 | P21554 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321230 | 0.91 | OPRK1 (0.80) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11690970 | 0.91 | OPRK1 (0.70) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL10741552 | 0.90 | OPRK1 (0.71) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL7327610 | 0.89 | OPRK1 (0.81) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11383138 | 0.89 | OPRK1 (0.74) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL10745544 | 0.89 | OPRK1 (0.74) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11075404 | 0.89 | OPRK1 (0.74) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11823022 | 0.89 | OPRK1 (0.73) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11083227 | 0.89 | OPRK1 (0.70) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11823357 | 0.89 | OPRK1 (0.73) | OPRK1HPGDSMN1; SMN2RECQLGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345931-B1 | CERTAIN PAF ANTAGONIST/ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1993-01-20 | — | — | EP | claimed |
| EP-0402422-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1990-12-19 | — | — | EP | claimed |
| EP-0345931-A1 | Certain PAF antagonist/antihistamine combinations and methods | SCHERING CORPORATION (US) | 1989-12-13 | — | — | EP | claimed |
| WO-1989010143-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | claimed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | claimed |
| US-5334592-A | Administering for allergic reactions; thienotriazolodiazepine compounds | SCHERING CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0345931-B1 | CERTAIN PAF ANTAGONIST/ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0402422-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0345931-A1 | Certain PAF antagonist/antihistamine combinations and methods | SCHERING CORPORATION (US) | 1989-12-13 | — | — | EP | disclosed |
| WO-1989010143-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | disclosed |
| US-4000289-A | 6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |