Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.81 |
| ▸ | HPGD | P15428 | 4/20 | 0.73 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.68 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.68 |
| ▸ | BRD4 | O60885 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11825237 | 0.93 | HPGD (0.73) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL11825820 | 0.93 | OPRK1 (0.70) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| Cyclohexane SCHEMBL11823207 | 0.91 | OPRK1 (0.68) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL11823022 | 0.91 | OPRK1 (0.73) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL10741552 | 0.90 | OPRK1 (0.71) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| Adinazolam SCHEMBL35430 | 0.89 | OPRK1 (1.00) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| Adinazolam SCHEMBL29358737 | 0.89 | OPRK1 (1.00) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL7323544 | 0.89 | OPRK1 (0.77) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL11833086 | 0.89 | OPRK1 (0.65) | OPRK1HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL11690970 | 0.89 | OPRK1 (0.70) | OPRK1HPGDGABRA1GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219541-B1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1989-09-20 | — | — | EP | claimed |
| EP-0219541-A1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES. | UPJOHN CO (US) | 1987-04-29 | — | — | EP | claimed |
| WO-1986006631-A2 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1986-11-20 | — | — | WO | claimed |
| US-4075221-A | ALKYLATION WITH DIALKYLMETHYLENEAMMONIUM SALT IN PRESENCE OF REACTIVE CARBOXYLIC ACYLATING AGENT | THE UPJOHN COMPANY (US) | 1978-02-21 | — | — | US | claimed |
| US-4012413-A | 1-(2-AMINOALKYL)-6-PHENYL-TRIAZOLO-BENZODIAZEPINE COMPOUNDS USED AS TRANQUILIZERS AND ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1977-03-15 | — | — | US | claimed |
| US-3969504-A | 6-Phenyl benzodiazepine antidepressants | THE UPJOHN CO. (US) | 1976-07-13 | — | — | US | claimed |
| EP-0219541-B1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1989-09-20 | — | — | EP | disclosed |
| EP-0219541-A1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES. | UPJOHN CO (US) | 1987-04-29 | — | — | EP | disclosed |
| WO-1986006631-A2 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1986-11-20 | — | — | WO | disclosed |
| US-4472397-A | Use of certain 1-substituted-triazolo-benzodiazepines to treat psychoses | THE UPJOHN COMPANY (US) | 1984-09-18 | — | — | US | disclosed |
| US-4075221-A | ALKYLATION WITH DIALKYLMETHYLENEAMMONIUM SALT IN PRESENCE OF REACTIVE CARBOXYLIC ACYLATING AGENT | THE UPJOHN COMPANY (US) | 1978-02-21 | — | — | US | disclosed |
| US-4012413-A | 1-(2-AMINOALKYL)-6-PHENYL-TRIAZOLO-BENZODIAZEPINE COMPOUNDS USED AS TRANQUILIZERS AND ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-3994941-A | METHYLOLATION, PHTHALIMIDATION | THE UPJOHN COMPANY (US) | 1976-11-30 | — | — | US | disclosed |
| US-3994940-A | Preparation of 1-(2-(dimethylamino)ethyl)-6-phenyl-4H-5-triazolo(4,3-a)(1,4)benzodiazepines | THE UPJOHN COMPANY (US) | 1976-11-30 | — | — | US | disclosed |
| US-3969504-A | 6-Phenyl benzodiazepine antidepressants | THE UPJOHN CO. (US) | 1976-07-13 | — | — | US | disclosed |