Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204703 | 0.84 | L3MBTL1 (0.54) | TDP1ALDH1A1PIN1TSHRMEN1 | |
| SCHEMBL5124456 | 0.84 | TDP1 (0.55) | TDP1ALDH1A1HTTPIN1TSHR | |
| SCHEMBL628126 | 0.84 | KMT2A (0.53) | TDP1PIN1TSHRMEN1NPC1 | |
| SCHEMBL9205212 | 0.84 | ALDH1A1 (0.50) | TDP1ALDH1A1PIN1TSHRMEN1 | |
| SCHEMBL29213724 | 0.83 | TDP1 (0.54) | TDP1ALDH1A1HTTPIN1TSHR | |
| SCHEMBL7323206 | 0.83 | ALDH1A1 (0.48) | TDP1ALDH1A1HTTPIN1TSHR | |
| SCHEMBL29249526 | 0.83 | TDP1 (0.54) | TDP1ALDH1A1HTTPIN1TSHR | |
| SCHEMBL10390030 | 0.80 | TSHR (0.51) | TDP1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL14026722 | 0.80 | KMT2A (0.41) | TDP1ALDH1A1PIN1TSHRMEN1 | |
| SCHEMBL9204917 | 0.80 | TSHR (0.44) | TDP1ALDH1A1HTTPIN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |