Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180298 | 0.79 | KMT2A (0.41) | GABRA1GABRB2SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL16951329 | 0.75 | GABRA1 (0.42) | TSHRGABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL982695 | 0.75 | TSHR (0.50) | TSHRGABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7323219 | 0.74 | GABRA1 (0.39) | GABRA1GABRB2ALDH1A1TP53KDM4E | |
| SCHEMBL6259721 | 0.72 | PPARA (0.48) | TSHRSMN1; SMN2ALDH1A1CYP3A4MGLL | |
| SCHEMBL8166933 | 0.72 | GABRA1 (0.44) | TSHRGABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1805352 | 0.71 | PPARG (0.43) | ALDH1A1CYP3A4L3MBTL1KMT2AMAPT | |
| SCHEMBL27641372 | 0.70 | TSHR (0.49) | TSHRGABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL13344106 | 0.70 | GABRA1 (0.43) | TSHRGABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL16954557 | 0.69 | MAPT (0.44) | TSHRGABRA1GABRB2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |